2-羧甲氧基苯甲醛苯甲酰腙及其配合物抑菌活性的构效关系

目的 :研究 2 羧甲氧基苯甲醛苯甲酰腙及其配合物的抑菌活性。方法 :合成配体 2 羧甲氧基苯甲醛苯甲酰腙及其配合物 ,采用K B法检测其对金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长抑制作用。结果 :配体 2 羧甲氧基苯甲醛苯甲酰腙仅抑制金黄色葡萄球菌的生长 ,其配合物能抑制金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长 ,形成抑菌环 ,尤其Cu配合物形成抑菌环直径最大。结论 :2 羧甲氧基苯甲醛苯甲酰腙与金属、稀土形成的配合物均有一定的抑菌作用 ,Cu配合物抑菌活性最强

Relationship of structure and bacteriostasis of 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone or their complexes

AIM: To study ba cteriostasis activities of ligand (2-(carboxymethoxyl) benzaldehyde benzoyl hyd razone (H 2L)) and their complexes. METHODS: Ligand H 2L and t heir complexes were synthesized. The bacteriostasis activities of H 2L and thei r complexes in vitro were tested with K-B method. RESUL TS: 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone only showed bact eriostasis activities on Staphyloccus aureus and their complexes had dramatic bacteriostasis activity on Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. Bacteri ostasis ring diameter of Cu-complex was largest. CONCLUSION: L igand H 2L complexes have bacteriostasis activities in vitro. B acteriostasis activities of Cu-complex are strongest among the complexes.