Dietary acrylamide intake and risk of breast cancer in the UK women's cohort |
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Authors: | Burley V J Greenwood D C Hepworth S J Fraser L K de Kok T M van Breda S G Kyrtopoulos S A Botsivali M Kleinjans J McKinney P A Cade J E |
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Affiliation: | Centre for Epidemiology and Biostatistics, University of Leeds, Leeds LS2 9JT, UK. |
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Abstract: | Background: No studies to date have demonstrated a clear association with breast cancer risk and dietary exposure to acrylamide.Methods: A 217-item food frequency questionnaire was used to estimate dietary acrylamide intake in 33 731 women aged 35–69 years from the UK Women''s Cohort Study followed up for a median of 11 years.Results: In all, 1084 incident breast cancers occurred during follow-up. There was no evidence of an overall association between acrylamide intake and breast cancer (hazard ratio=1.08 per 10 μg day−1, 95% CI: 0.98–1.18, Ptrend=0.1). There was a suggestion of a possible weak positive association between dietary acrylamide intake and premenopausal breast cancer after adjustment for potential confounders (hazard ratio=1.2, 95% CI: 1.0–1.3, Ptrend=0.008). There was no suggestion of any association for postmenopausal breast cancer (hazard ratio=1.0, 95% CI: 0.9–1.1, Ptrend=0.99).Conclusions: There is no evidence of an association between dietary acrylamide intake and breast cancer. A weak association may exist with premenopausal breast cancer, but requires further investigation. |
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Keywords: | cohort study acrylamide diet breast cancer |
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