GW112蛋白在乳腺癌组织中表达及意义

目的探讨GW112蛋白在乳腺癌组织中的表达情况及其与临床病理因素间的相关性。方法应用Westernblot和免疫组织化学法检测乳腺增生、不典型增生、乳腺癌组织和相应癌旁组织中GW112蛋白表达水平。结果乳腺癌组织中GW112蛋白表达量（1．09±0．14）及阳性表达率（61．7％）明显高于癌旁组织（0．41±0．19，0）（P〈0．05）；GW112蛋白表达水平从乳腺增生、不典型增生到乳腺癌组织依次增强，各组间比较差异均有统计学意义（P〈0．05）；乳腺癌组织中GW112蛋白阳性表达与肿瘤直径、是否发生腋窝淋巴结转移密切相关（P〈0．05）。结论GW112蛋白在乳腺癌发生、发展和淋巴结转移中起重要作用，可能成为乳腺癌临床治疗的新靶点。

Expression of GW112 protein in breast cancer and its clinical significance

Objective To investigate the expression of GWll2 protein in breast cancer and its correlation with clinicopathologic factors. Methods Western blot and immunohistochemistry technique were used to detect the expression of GW112 protein in mastoplasia, atypical hyperplasia, breast cancer and adjacent normal tissues. Results The expression level and positive rate of GW112 protein were significantly higher in breast cancer tissues （1. 09 ± 0. 14, 61.7%） than those in adjacent normal tissues （0.41±0.19, 0） （P〈0.05）. GW112 protein increased from low level to a higher level in turn of mastoplasia tissue, atypical hyperplasia tissue and breast cancer tissue, showing a significant difference between every two groups （P〈0.05）. The positive expression of GW112 protein was closely correlated with tumor size and axillary lymph node metastasis （P〈0.05）. Conclusions GW112 protein plays an important role in the development and progression of breast cancer and lymph node metastasis, and it might be an target for clinical therapy of breast cancer.