周围动脉病变程度与血清胱抑素C水平相关分析

目的研究周围动脉病变（peripheral arterial disease,PAD）程度与血清胱抑素C（serum cystatin C,Cys C）水平的相关性。方法回顾性分析142例拟诊周围动脉病变而行血管超声检查患者的临床资料,以周围动脉斑块数目对病变程度进行定量评估,分析PAD病变程度与血清Cys C水平及其他危险因素的相关关系。结果 PAD患者血清Cys C水平较对照组升高（P〈0.05）,并随着病变程度加重进一步升高。PAD病变程度与血清Cys C水平呈直线相关（P〈0.05）。多元线性回归分析显示,PAD病变程度与年龄、周围动脉内-中膜厚度、血清Cys C水平、性别相关（P〈0.05）。结论 PAD病变程度与血清Cys C水平有一定的相关性,血清Cys C水平与可作为预测PAD病变程度的参考指标。

Correlation of serum cystatin C levels with the severity of peripheral arterial disease

Objective To investigate the correlation of serum cystatin C（ Cys C） levels with the severity of peripheral arterial disease（ PAD）. Methods One hundred and forty tw o patients w ith suspected PAD w ere enrolled in the study. The peripheral arterial plaques w ere assessed by ultrasonography and serum Cys C levels w ere measured. Results The serum Cys C levels in PAD patients w ere higher than those in control group（ P〈0. 05）; and further increased w ith the severity of lesions in PAD patients（ P〈0. 05）. The severity of PAD w as linearly correlated w ith the levels of serum Cys C,age,male sex and MIT（ P〈0. 05）. Conclusion Serum Cys C level is correlated w ith PAD severity,and may be used as an indicator for the severity of peripheral arterial disease.