| 喀什地区维吾尔族妇女血脂水平与子宫颈病变相关性 |
| |
| 引用本文： | 张微,;阿曼古丽,;杨兰,;美丽古丽·莫合买提,;王英红,;陶林,;李述刚,;张宏彦,;曹玉广,;李锋,;张文杰.喀什地区维吾尔族妇女血脂水平与子宫颈病变相关性[J].河南诊断与治疗杂志,2014(7):655-657. |
| |
| 作者姓名： | 张微 ;阿曼古丽 ;杨兰 ;美丽古丽·莫合买提 ;王英红 ;陶林 ;李述刚 ;张宏彦 ;曹玉广 ;李锋 ;张文杰 |
| |
| 作者单位： | [1]石河子大学医学院病理系石河子大学新疆地方与民族高发病教育部重点实验室,新疆石河子832002; [2]石河子大学医学院第一附属医院妇产科,新疆石河子832002; [3]石河子大学医学院预防医学系,新疆石河子832002; [4]西安市疾病预防控制中心,西安710054; [5]华中科技大学同济医学院公共卫生学院流行病及统计学教研室,武汉430030 |
| |
| 基金项目： | 科技部“十一五”科技支撑计划项目（2009BA182802）;国际科技合作与交流专项（2010DFB34100）. |
| |
| 摘 要： | 目的探讨喀什地区维吾尔族（维族）妇女血脂水平与子宫颈病变及其病变程度的相关性。方法 79例子宫颈病变患者为观察组,其中CIN 1级57例,CIN 2级14例,CIN 3级5例,宫颈癌3例;无子宫颈病变者158例为对照组。检测2组血脂水平,采用logistic回归分析血脂水平对罹患子宫颈病变的相对危险度,采用Spearman相关分析法分析子宫颈病变程度与血脂水平间相关性。结果观察组总胆固醇（total cholesterol,TC）（（4.29±0.90）mmol/L）、低密度脂蛋白胆固醇（low density lipoprotein-cholesterol,LDL-C）（（2.43±0.70）mmol/L）和三酰甘油（triacylglycerol,TG）（（1.17±0.80）mmol/L）水平均高于对照组（（3.35±1.10）、（1.95±0.80）和（0.87±0.50）mmol/L）（P〈0.05）,高密度脂蛋白胆固醇（high density lipoprotein-cholesterol,HDL-C）水平与对照组比较差异无统计学意义（P〉0.05）;高TG水平（OR=5.529,95%CI：1.481-20.647,P=0.011）和低HDL-C水平（OR=0.420,95%CI：0.224-0.788,P=0.007）为患子宫颈疾病的危险因素;TC和LDL-C水平与子宫颈病变程度呈正相关（r=0.314,P=0.005;r=0.398,P=0.000）。结论血清高TG和低HDL-C水平可能增加患子宫颈病变的风险;子宫颈病变患者TC和LDL-C水平升高可能与病变进展有关。
|
| 关 键 词： | 子宫颈癌 宫颈上皮内瘤变 CIN 肥胖 维吾尔族 血脂水平 |
Correlations of blood women lipid levels with cervical lesions among Uygur in Kashi Prefecture of Xinjiang |
| |
| Institution: | ZHANG Wei , Amanguli A, YANG Lan, Meiliguli MOHEMAITI, WANG Ying-hong, TAO Lin, LI Shu-gang, ZHANG Hong-yan, CAO Yu-guang, LI Feng, ZHANG Wen-jie (Department of Pathology, Shihezi University School of Medical, the Key Laboratory for Xinjiang Endemic and Ethnic Diseases of Ministry of Education, Shihezi University, Shihezi 832002, China) |
| |
| Abstract: | Objective To investigate the associations of cervical lesions with blood lipid levels among Uygur women in Kashi Prefecture. Methods Seventy-nine patients with cervical lesion （observation group） included 57 cases of CIN1, 14 cases of CIN2, 5 cases of CIN3 and 3 cases of cervical cancer. Another 158 individuals with no cervical lesions were as controls （control group）. The blood lipid level was detected in two groups, logistic regression analysis was performed for the relative risk of cervical lesions in different blood lipid levels, and Spearman correlation analysis was used to analyze the correlation between degree of cervical lesions and blood lipid levels. Results The levels of total cholesterol （TC）, low density lipoprotein-cholesterol （LDL-C） and triacylglycerol （TG） were higher in observation group （（4. 29 ± 0. 90）, （2.43±0.70）, （1.17±0.80） mmol/L） than those in control group （3.35±1. 10）,（1.95±0.80） and （0.87±0.50） mmol/L） （P〈0.05）, and there was no significant difference in the level of high density lipoprotein-cholesterol （HDL-C） between two groups （P〈0.05）. High TG level （OR=5.529, 95% CI：1.481 to 20. 647, P=0.011） and low HDL-C level （OR=0. 420, 95%CI： 0. 224 to 0. 788, P：0. 007） were the risk factors of cervical lesions. The levels of TC （r=0. 314, P=0. 005） and LDL-C （r= 0. 398, P = 0. 000） were positively correlated with the degree of cervical lesions. Conclusions High TG level and low HDL-C level may increase the risk of cervical lesions. The elevated levels of TC and LDL-C may be involved in the progression of cervical lesions. |
| |
| Keywords: | Cervical cancer cervical intraepithelial neoplasia CIN obesity Uygur blood lipid level |
| 本文献已被 维普 等数据库收录！ |
|
