2型糖尿病患者的临床流行特征及其与骨质疏松症的关系

目的 了解2型糖尿病患者的流行病学特征及临床特征,以及并发骨质疏松症的情况.方法 回顾性分析近1 a来在云南省某省级医院住院的137例2型糖尿病住院患者,收集住院相关信息,分析其并发骨质疏松症的相关特征及其影响因素等情况.采用SPSS软件进行描述性分析、单因素分析及Logistic逐步回归分析.结果 137例2型糖尿病患者中男性占40.9％,女性占59.1％.年龄(59.96±11.73)岁,137例2型糖尿病患者中并发骨质疏松症的占35.80％ (49/137),其中男性17例占34.70％ (17/49),女性32例占65.3％ (32/49),主要以61～75岁为主,有28例占57.1％.未患骨质疏松症的占64.20％ (88/137).单因素分析结果显示,各年龄段的2型糖尿病患者并发骨质疏松症构成差异有统计学意义(P＜0.05)、患病病程不同的2型糖尿病患者并发骨质疏松症构成有差异有统计学意义(P＜0.05).Logistic逐步回归结果显示,有统计学意义的危险因素为2型糖尿病患者病程(P＜0.05)、血Ca值(P＜0.05).结论 2型糖尿病患者中女性构成高于男性,年龄以61～75岁为主,体重偏于正常体重.并发骨质疏松症者,女性构成高于男性,病程时间较长以＞120月为主,血糖值和糖化血红蛋白值轻度偏高,而且提示病程时间越长者并发骨质疏松症的构成风险越大;血Ca值越少者并发骨质疏松症的构成风险越大.

Epidemiological and Clinical Features of 2 Diabetes Mellitus Cases and Relationships between T2DM and Osteoporosis

Objective To understand the epidemiological characteristics and clinical characteristics of type 2 diabetes mellitus,and the subsequent osteoporosis.Methods 137 cases of type 2 diabetes mellitus were randomly selected from one hospital from Feb 1st,2011 to Jan 31th,2012,and the outpatient records and medical record were collected including general population index,general biochemical indicators,and diabetes mellitus with osteoporosis related diagnosis index.The influencing factors of osteoporosis were analyzed.The descriptive analysis,unviable analysis and multi-viable analysis was used by SPSS software.Results Proportion of male accounted for 40.9% and female 59.1%.The average age was 59.96 ±11.73 years old.The percentage of osteoporosis with type 2 diabetes mellitus was 35.80%(49/137),in which male accounted for 34.70%(17/49) and female 65.3%(32/49).Unviable analysis showed that period(P<0.05) and the blood Ca(P<0.05) were the influencing factors for the proportion of osteoporosis with type 2 diabetes mellitus.Statistically significant risk factors by Logistic regression were:blood Ca(OR=0.3738) and period(OR=1.033).Conclusion The proportion of female is higher than male among patients with type 2 diabetes mellitus,and the majority of patients are in the age group from 61 to 75 years old.Duration of type 2 diabetes mellitus and blood Ca are associated with osteoporosis of type 2 diabetes mellitus.