孤独症儿童脑干听觉诱发电位及耳声发射研究

目的探讨孤独症对听觉系统功能的影响，为临床诊治提供理论依据。方法对20例孤独症患儿进行听觉脑干诱发电位（auditory brainstem response，ABR）及畸变产物耳声发射（distortion Product otoacoustic emission，DPOAE）测试，设立同年龄段正常组进行对照研究。结果①孤独症组ABR双耳Ⅴ波潜伏期、右耳Ⅰ～Ⅴ波间期、Ⅲ～Ⅴ波间期延长，与对照组比较有显著性差异（P〈0．05）；②孤独症组DPOAE异常率增高，1kHz及1．5kHz平均幅值及1kHz引出率降低，与对照组比较有显著性差异（P〈0．05）。结论孤独症儿童ABR潜伏期延长，DPOAE测试异常率增高，提示脑干听觉通路传导异常，可能是引起孤独症儿童广泛感觉系统发育障碍，使言语、认知、社会等方面异常发育的原因之一。

Auditory brainstem response and DPOAE in autism children

OBJECTIVE To explore the audiological characteristics in children with autism. METHODS A group of 20 children with autistic disorder were included in an investigation of auditory brain stem responses （ABR） and distortion product otoacoustic emissions （DPOAE） . The results were compared with those in 18 normal children of agematched. RESULTS （1）As compared with the Values in the control group, the latency of wave Ⅴ for both ears,wave Ⅰ-Ⅴ and wave Ⅲ-Ⅴ intervals for the right were significantly prolonged （P〈0.05） in the ASD group. （2）The occurrence rate of abnormal DPOAE in the ASD group was higher than that in the control group; When compared with control group,the DPOAE amplitudes at frequency of 1 kHz and 1.5 kHz and the occurrence rate at 1 kHz was lower （P〈0.05） in the ASD group. CONCLUSION Children with autistic disorder have longer ABR latency and abnormal DPOAE; The brainstem abnormalities may be partly responsible for deviant language,cognitive,and social development in children with ASD.