盐酸右美托咪定在联合阻滞麻醉下经尿道前列腺电切手术中的应用

目的：观察盐酸右美托咪定在经尿道前列腺电切手术中的临床应用。方法选择择期行经尿道前列腺电切术患者80例，随机分为两组，每组各40例。D组为右美托咪定组，C组为对照组。观察并记录两组患者麻醉前（T0），麻醉平面固定后（T1），体位变为截石位后10min（T2），截石位后50min（T3），手术结束时（T4）的心率（HR），平均动脉压（MAP），以及Ramsay镇静评分。结果C组在T2、T3、T4时间点的HR和MAP明显高于D组，Ramsay镇静评分低于D组（P＜0.05），D组在T2、T3、T4时的HR、MAP明显低于T0，T2时Ramsay评分高于T0（P＜0.05）。两组患者术中躁动、寒颤发生率比较差异有统计学意义（ P＜0.05）。结论盐酸右美托咪定应用在联合阻滞麻醉下经尿道前列腺电切术中能够提供良好的镇静作用，且对血流动力学影响小，利于手术顺利进行。

The application of dexmedetomidine hydrochloride in transurethral resection of prostate under combined anesthesia

Objective To observate the clinical application of dexmedetomidine hydrochloride in transurethral resection of prostate operation. Methods 80 cases patients undergoing transurethral resection of prostate, were randomLy divided into two groups, 40 cases in each group. Group D for dexmedetomidine group, and group C as control group. The heart rate （HR）, mean arterial pressure （MAP）, and Ramsay sedation score of two groups of patients before anesthesia （T0）,the level of anesthesia after fixation （T1）, 10min after fixed position into the lithotomy position （T2）, 50min after lithotomy position （T3） at the end of operation （T4） were observed and recorded. Results Compared with group D , HR and MAP of the group C in T2, T3, T4 time point was significantly higher, Ramsay sedation score was significantly lower （P〈0.05）. HR and MAP of the group D in T2, T3,T4 time point was significantly lower than that of T0, and the Ramsay sedation score in T2 was higher than that of T0 （P〈0.05）.Compared the incidence of agitation and shivering with patients in two groups, the difference was statistically significant （P 〈 0.05）. Conclusion Dexmedetomidine hydrochloride uses in combined anesthesia in transurethral resection of prostate can provide good sedation, and with little effect on hemodynamics, conducive to the operation smoothly.