中国洛阳地区汉族人MHC补体单倍型的分析

应用国际补体参考实验室的方法，对洛阳地区正常汉族家系１８４条染色体做了补体单倍型的检测与分析，并与南方汉族做了比较，共发现频率大于０．０１的补体单倍型１９个，频率居前３位者为ＳＣ３１（０．２１７４）ＳＣ４２（０．１６８５）和ＳＣ３２（０．１０８７）有１１个型别呈连锁不平衡。Ｂｆ．Ｃ２，Ｃ４Ａ和Ｃ４Ｂ等位基因的频率分别以Ｂｆ．Ｓ，Ｃ２．Ｃ４Ａ３，Ｃ４Ａ４，Ｃ４Ｂ１和Ｃ４Ｂ２频率居高，而且洛阳汉族Ｂｆ

Analysis of MHC complotype of Han nationality Chinese in Luoyang area

The complotype of 184 chromosomes from healthy Han nationality Chinese families was firstly investigated and analyzed in Luoyang area, by using methods of the international complement reference laboratory. And the data from Luoyang Han were compared with those of Southern Han Chinese. The results showed that 19 various complotypes which frequencies were more than 0.01 were identified. There were 11 complotypes with linkage disequilibria. The preceding three complotypes were SC31(0.2174), SC42(0.1685) and SC32(0.1087). The highest allele frequencies of four loci of complotypes were Bf *S, C2 *C, C4A *3, C4A *4, C4B *1 and C4B *2 respectively. And the alleles Bf *S, C2 *C and C4B *3 frequencies were obvious higher in Luoyang Han than those in Guangdong Han with statistically significant difference( P <0.05, or 0.01). Moreover, the major complotype frequencies of Chinese Han, Japanese, Caucasoid and Negroid were compared and discussed. Conclusions. The distribution of complotype patterns and frequencies of Northern Han are elucidated and the allele frequency differences between Northern and Southern Han nationality Chinese. are also showed.