Mapping of a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26 |
| |
Authors: | Caspari R Uhlhaas S Friedl W Knapp M Propping P |
| |
Affiliation: | Medizinische Klinik I, Universit?t Bonn, Germany. caspari@uni-bonn.de |
| |
Abstract: | Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 in a German family with nonspecific X-linked mental retardation (MRX 75, HUGO Human Gene Nomenclature Committee). Two point linkage analysis with 23 informative markers gave a lod score of 2.53 at theta = 0 for markers DXS425, DXS1254, DXS1114, and HPRT. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|