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Reduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cells |
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| Authors: | Iain Brown Kawan Shalli Sarah L McDonald Susan E Moir Andrew W Hutcheon Steven D Heys Andrew C Schofield |
| Affiliation: | (1) Department of Surgery, University of Aberdeen, Medical School, Aberdeen, UK;(2) Department of Medical Oncology, Grampian University Hospitals NHS Trust, Aberdeen Royal Infirmary, Aberdeen, UK;(3) Department of Molecular and Cell Biology, University of Aberdeen, Medical School, Aberdeen, UK |
| Abstract: | IntroductionDocetaxel is one of the most effective chemotherapeutic agents in the treatment of breast cancer. Breast cancers can have an inherent or acquired resistance to docetaxel but the causes of this resistance remain unclear. However, apoptosis and cell cycle regulation are key mechanisms by which most chemotherapeutic agents exert their cytotoxic effects. |
| Keywords: | breast cancer docetaxel drug resistance gene expression p27 |
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