短程、低剂量新三联疗法治疗HP阳性十二指肠溃疡

目的比较两种不同的三联疗法治疗幽门螺旋杆菌(HP)阳性的十二指肠溃疡,筛选出短程、低剂量的新三联方案.方法8 0例患者随机分为两组(n=4 0).研究组施以短程、低剂量三联疗法,口服铋剂1 2 0mg qid 阿莫西林0.5g bid 呋喃唑酮0.1 g tid;对照组为洛塞克40mg qd 克拉霉素0.5 tid 甲硝唑0.4 bid,疗程均为2周.观察治疗后疗效、HP转阴率、药物不良反应、药费及4周后渍疡复发率和HP再感染率.结果与对照组相比,研究组治疗有效率、HP转阴率和不良反应率大致相同(P＞0.05),而4周后溃疡复发率和HP再感染率明显优于对照组(P＜0.05),药费也仅占1/2.结论短程、低剂量新三联疗法是HP阳性十二指肠溃疡有效、安全、价廉的方案.

Comparison of Two Triple-therapy for Short-phase and Low-dosal in the Treatments Helicobacter Pylori-infectious Duodenal Ulcer

Objective To compare two different triple-therapy for Helicobacter Pylori (HP)-infectiousduodenal ulcer(DU). Methods Eighty patients with PH-infectious DU were randomly divided into 2 groups(n=40). The Study group was treated orally with new short-phase and low-dosal therapy (bismuth 120mg qid+ amoxpcpllin 0.5g bid + furazolidone 0.1g tid); the Control group were subjected to standard method(losec 40mg qd + clarithromycin 0.5g tid + metronidazole 0.4g bid), continuously for 2 weeks. The ratesof efficacy and HP eradication, side-effects and costs were analyzed, as well as the DU recurrence andHP recrudescence after 4 weeks. Results In both group, the rates of efficacy and HP eradication andside-effects showed no significant difference(P>0.05), but the rates of DU recurrence and HP recrudes-cence were statistical difference after 4 weeks(P<0.05), and the cost of Study group was only half ofthe others. Conclusions The new therapy is effective, safe and cheap in short-phase and low-dosaltreatment to HP-associated DU.