新生儿败血症血清降钙素原的动态改变

目的：探讨新生儿败血症患儿血中降钙素原(procalcitonin PCT)的改变。方法：以放免方法检测24例新生儿败血症患儿血中PCT的改变，同时检测20例缺血缺氧性脑病(HIE)以及16例正常足月儿作为正常对照。结果：新生儿败血症患儿在急性期PCT较正常对照组明显升高［(112.23±10.13) μg/L vs (8.65±2.14) μg/L］, (P0.05)；而HIE组患儿PCT与正常对照组比较无明显的差别。结论：新生儿败血症患儿在急性期血中PCT明显增高,对败血症的早期诊断有一定的价值。

Dynamic Variations of Serum Procalcitonin Levels in Neonates with Sepsis

Objective To study the changes of serum procalcitonin (PCT) in neonates with sepsis. Methods Serum PCT was determined using an immunoradiometric assay in 20 newborn infants with neonatal sepsis, 24 neonates with hypoxic ischemic encephalopathy (HIE) and 16 healthy newborn controls. Results Increased levels of serum PCT were found in neonates with sepsis compared with the control group ( 112.23 ± 10.13 ) μg/L vs ( 8.65 ± 2.14 ) μg/L], (P< 0.01 ). After 1 week of treatment with appropriate antibiotics, PCT levels returned to normal. There was no difference between HIE neonates and the control group. Conclusions Elevated serum PCT levels are noted in neonatal sepsis. PCT might be of value in the diagnosis of neonatal sepsis.