Fenfluramine long-term administration and brain serotonin |
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| Authors: | Jacques Duhault Michele Boulanger |
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| Affiliation: | Department of Biochemical Pharmacology, Institut de Recherches Services, 14 Rue du Val d''Or 92150 Suresnes, France |
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| Abstract: | Long-term administration of fenfluramine induced a decrease of brain 5-HT to the same extent as did an acute dose. 48 h after drug withdrawal, the brain serotonin level returned to the control value. The present study provides evidence to suggest that a degenerative lesion of 5-HT neurons is not involved in fenfluramine activity. |
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| Keywords: | Fenfluramin Serotonin |
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