| 来曲唑和HMG在克罗米芬抵抗的多囊卵巢综合征患者中诱发排卵的效果 |
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| 引用本文： | 石少权,姜芳芳,洪婷,王桂荣,王峰. 来曲唑和HMG在克罗米芬抵抗的多囊卵巢综合征患者中诱发排卵的效果[J]. 中国现代应用药学, 2013, 30(7): 782-785 |
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| 作者姓名： | 石少权 姜芳芳 洪婷 王桂荣 王峰 |
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| 作者单位： | 中山大学附属第五医院妇产科，广东 珠海 519000;中山大学附属第五医院妇产科，广东 珠海 519000;中山大学附属第五医院妇产科，广东 珠海 519000;中山大学附属第五医院妇产科，广东 珠海 519000;中山大学附属第五医院妇产科，广东 珠海 519000 |
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| 摘 要： | 目的 比较来曲唑和人绝经期促性腺激素(HMG)治疗克罗米芬(CC)抵抗的多囊卵巢综合征(PCOS)患者的效果。方法 把克罗米芬抵抗的PCOS不孕症患者93例随机分为2组：来曲唑组49例，HMG组44例。来曲唑组从月经结束第3天至第7天(d 3-7)给予来曲唑5 mg?d-1口服，共5 d；HMG组d 3-7给予HMG 75 U?d-1肌注。所有患者当超声监测到至少有1个成熟卵泡平均直径≥18 mm时，肌内注射HCG 10 000 U诱发排卵。阴道B超监测卵泡发育和子宫内膜厚度。结果 2组有排卵周期数差异无统计学意义(78.91% vs 82.14%，P>0.05)；HMG组≥2个成熟卵泡周期数高于来曲唑组(P<0.01)。2组周期妊娠率(23.44% vs 24.11%，P>0.05)和流产率(6.67% vs 11.11%，P>0.05)差异无统计学意义。来曲唑组没有多胎妊娠，HMG组有5例多胎妊娠(18.52%，5/27)。HCG注射日子宫内膜厚度2组差异无统计学意义[(9.88±1.96)mm vs (10.47±1.62)mm，P>0.05]；来曲唑组血清雌二醇(E2)低于HMG组[(261.43±199.35)pg?mL-1 vs (408.74±297.48)pg?mL-1，P<0.01]；卵巢囊肿发生率低于HMG组(P<0.05)。来曲唑组无卵巢过度刺激综合征发生；HMG组卵巢过度刺激综合征发生率3.57%。结论 来曲唑诱发排卵可以获得与促性腺激素相似的排卵率和妊娠率，而降低了与治疗相关的风险，可以作为克罗米芬抵抗的多囊卵巢综合征患者有效的诱发排卵选择。
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| 关 键 词： | 芳香化酶抑制剂；促性腺激素；多囊卵巢综合征；克罗米芬抵抗；诱发排卵 |
| 收稿时间： | 2012-11-29 |
| 修稿时间： | 2013-02-22 |
Efficacy of Letrozole and Human Menopausal Gonadotropin for Ovulation Induction in Clomiphene Resisance Polycystic Ovary Syndrome Patients |
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| SHI Shaoquan,JIANG Fangfang,HONG Ting,WANG Guirong and WANG Feng. Efficacy of Letrozole and Human Menopausal Gonadotropin for Ovulation Induction in Clomiphene Resisance Polycystic Ovary Syndrome Patients[J]. The Chinese Journal of Modern Applied Pharmacy, 2013, 30(7): 782-785 |
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| Authors: | SHI Shaoquan JIANG Fangfang HONG Ting WANG Guirong WANG Feng |
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| Affiliation: | Department of Gynecology and Obstetrecs in the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China;Department of Gynecology and Obstetrecs in the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China;Department of Gynecology and Obstetrecs in the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China;Department of Gynecology and Obstetrecs in the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China;Department of Gynecology and Obstetrecs in the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China |
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| Abstract: | |
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| Keywords: | aromatase inhibitor gonadotropin polycystic ovary syndrome clomiphene resisance ovulation induction |
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