| 电针抗吗啡戒断后焦虑的5-HT_(1A)受体作用机理研究 |
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| 引用本文： | 李亮,周奇志,赵纪岚,孟都,蔡定均,吴巧凤,乔秀兰.电针抗吗啡戒断后焦虑的5-HT_(1A)受体作用机理研究[J].辽宁中医杂志,2008,35(11):1763-1765. |
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| 作者姓名： | 李亮 周奇志 赵纪岚 孟都 蔡定均 吴巧凤 乔秀兰 |
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| 作者单位： | [1]成都中医药大学针灸推拿学院,四川成都610075 [2]成都中医药大学附属医院,四川成都610072 |
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| 基金项目： | 四川省中医管理局课题(2004A20); 四川省教育厅自然科学科研项目(2003C101) |
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| 摘 要： | 目的:探讨电针抗吗啡戒断后焦虑的5-HT1A受体作用机理。方法:建立吗啡依赖戒断小鼠模型,分别予模型小鼠皮下连续注射5-HT1A受体激动剂(8-OH-DPAT)或拮抗剂(WAY-100635),并予电针治疗后,以高架十字迷宫测试小鼠焦虑情绪。结果:(1)电针和8-OH-DPAT均可提高模型小鼠的OT%和OE%值(P<0.05)。(2)电针可明显提高注射WAY-100635的模型小鼠的OT%和OE%值(P<0.05)。结论:5-HT1A受体在抗焦虑过程中起重要作用,它可能是电针抗焦虑的重要中枢作用途径之一。
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| 关 键 词： | 吗啡戒断 焦虑 电针 5-HT1A受体 8-OH-DPAT WAY-100635 |
Mechanism of Electro-acupuncture on 5-HT1A Receptor in the Anxious Mice after Morphine Withdrawal |
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| LI Liang,ZHOU Qi-zhi,ZHAO Ji-lan,MENG Du,CAI Ding-jun,WU Qiao-feng,QIAO Xiu-lan.Mechanism of Electro-acupuncture on 5-HT1A Receptor in the Anxious Mice after Morphine Withdrawal[J].Liaoning Journal of Traditional Chinese Medicine,2008,35(11):1763-1765. |
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| Authors: | LI Liang ZHOU Qi-zhi ZHAO Ji-lan MENG Du CAI Ding-jun WU Qiao-feng QIAO Xiu-lan |
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| Institution: | LI Liang1,ZHOU Qi-zhi1,ZHAO Ji-lan1,MENG Du2,CAI Ding-jun1,WU Qiao-feng1,QIAO Xiu-lan1 (1.College of Acupuncture & Tuina,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China,2.The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China) |
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| Abstract: | Objective: To research the mechanism of electro-acupuncture on 5-HT1A receptor in the anxious mice after morphine withdrawal.Methods: Established a morphine withdrawl mice model,and then observed the model injected 5-HT1A receptor agonist(8-OH-DPAT) or antagonist(WAY-100635) with Elevated Plus-maze after electro-acupuncture treatment.Results:(1)Both of electro-acupuncture treatment and 8-OH-DPAT could raise the value of OT% & OE%(P<0.05) of the model mice.(2)Electro-acupuncture treatment could raise the val... |
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| Keywords: | Morphine withdrawal Anxiety Electro-acupuncture 5-HT1A R eceptor 8-OH-DPAT WAY-100635 |
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