包皮环切术对男性高危型HPV感染的预防作用研究

目的探讨包皮环切术对男性高危型HPV感染的预防作用。方法收集我院2001年6月至2010年6月十年间普外门诊行包皮环切术的患者临床资料276例,另取我院体检中心体检的包皮过长而未行包皮环切术的健康男性276例作为对照。HPV-DNA分型基因芯片检测高危型HPV病毒的表达。结果 552例受试者中共检测到高危型HPV感染157例,感染率为28.4%。治疗前治疗组感染80例,感染率为29.0%;对照组感染77例,感染率为27.9%,两组之间无显著性差异(P>0.05)。包皮环切术后2年,治疗组高危型HPV感染率从29.0%减少到11.9%,二者之间具有显著性差异(P<0.05)。对照组为29.3%,与治疗前无显著性改变(P>0.05)。结论包皮环切术可以预防男性高危型HPV的感染,值得积极推广应用。

The Effect of Circumcision on Infection of High-risk Human Papilloma Virus in Adult Males

Objective To investigate the clinical effects of circumcision on infection of high-risk human papilloma virus （HPV） in adult males. Methods A total of 276 adult males with circumcision were collected and analyzed in our hospital. Another 276 phimosis without circumcision were recruited in the control group. The high-risk HPV was detected by HPV-DNA genotyping chip. Results 157 cases were infected by high-risk HPV in 552 phimosis, and the infection rate was 28.4%. Before Circumcision, 80 cases were infected by high-risk HPV with an infection rate of 29.0% in treatment group, and 77 cases were infected by high-risk HPV with an infection rate of 27.9% in control group. There was no significant difference between the two groups （P 〉 0.05） . After circumcision, the infection rate of high-risk HPV was significantly decreased from 29.0% to 11.9% in treatment group （P〈 0.05 ） . However, the infection rate of high-risk HPV was 29.3% in control group and no significant difference was found cmparing with two years ago （P〉 0.05） . Conclusion Circumcision can effectively reduce high-risk HPV infection, and which was worthy to promote the clinical application.