寻找物质基础非当前中药现代化关键

从寻找药效物质基础是否可能是必要以及成分不明能否实行中药质控三方面论述了寻找物质基础非当前中药现代化关键。指出成分清楚，机制明确及高效，速效等并非是现代中药所必需的特征，分离寻找药效物质基础不是当前中药现代化的首要任务，在成分未完全明了的基础上进行中药质控和建立具有中医药特色的药效评估体系是中药现代化关键，中药质控应强调多环节，多手段和整体特征性模糊识别，而药效评估应在方法学符合现代科学基础上，注重体现中药整体多系统调整，温和缓效，证效相关的作用特点，并与质控相联系进行研究。

No key relevant to modernization of Chinese materia medica by searching efficacy substance

The question that searching efficacy substance is not the key relevant to modernization of Chinese materia medica (CMM) was discussed in the following three aspects: its possibility, necessity and the feasibility of quality control without knowing the effect substance. It is pointed out that definite understandings of active components and mechamism, high and immediate efficacy are not the necessary characteristics of CMM. Searching the active ingredients is not main task for the modernization of CMM. On the basis of not completely knowing the active components, quality control and establishing standard system of evaluating herbal medicine efficacy with the characteristics of TCM are two key problems. The quality control of herbal medicine should be concentrated on multi steps, multi means and vague recognition of general characters. The characteristics of multi systematic, mild and slow, and pattern associated effects should be seriously considered in assessing herb efficacy on the prerequisite of being methodologically in accordance with modern science. In the meantime, the quality control study of herbal medicine must be on such a basis.