Aerogenic vaccination of mice with Mycobacterium bovis BCG |
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| Authors: | I M Orme F M Collins |
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| Affiliation: | 1. Univ Paris-Sud Institut Galien Paris-Sud, CNRS UMR 8612, LabEx LERMIT, Châtenay-Malabry, France;2. University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutics Department, 41-43 Dinh Tien Hoang, District 1, Ho Chi Minh City, Viet Nam;3. Ton Duc Thang University, Faculty of Applied Science, Division of Pharmacotechnology and Biopharmacy, Ho Chi Minh City, Viet Nam;1. Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA;2. Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA;3. Department of Immunology, Harvard Medical School, Boston, MA, USA;1. South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa;2. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre, Nijmegen, Geert Grooteplein 8, 6525 GA Nijmegen, the Netherlands;3. Department of Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Germany;4. Bill & Melinda Gates Foundation, Division of Global Health, Washington DC, United States;1. Department of Neurobiology & Behavior, UC Irvine, Irvine, CA 92697, USA;2. Sue and Bill Gross Stem Cell Research Center, UC Irvine, Irvine, CA 92697, USA;3. Mathematical, Computational and System Biology (MCSB) Program, UC Irvine, Irvine, CA 92697, USA;4. Institute for Memory Impairments and Neurological Disorders, UC Irvine, Irvine, CA 92697, USA;5. Department of Pathology & Laboratory Medicine, UC Irvine, Irvine, CA 92697, USA;6. Mater Research Institute-University of Queensland, Brisbane, Australia;7. University of Edinburgh Centre for Inflammation Research, Edinburgh, UK;8. Simons Initiative for the Developing Brain Centre, University of Edinburgh, Edinburgh, UK;9. The Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh, UK;1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;2. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine and Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15261, USA;3. Department of Immunology and Microbiology, University of Colorado, Anschuntz Medical Campus, Aurora, CO 80045, USA;4. Ragon Institute of Massachusetts General Hospital, MIT and Harvard, Cambridge, MA 02139, USA;5. Department of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children’s Hospital of Pittsburgh, and Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15620, USA;6. Division of Animal Laboratory Resources, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA;7. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA;8. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA |
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| Abstract: | The course of infection with Mycobacterium bovis BCG Pasteur was followed against time in groups of mice vaccinated by either the aerogenic or subcutaneous route. The generation of acquired protective immunity and immunological memory was determined in each group by adoptive immunisation procedures. In addition, subcutaneously vaccinated mice were tested for their ability to resist an aerogenic challenge with a lethal dose of M. tuberculosis. No overall qualitative differences in the magnitude or longevity of antituberculosis immunity in mice vaccinated by the two procedures were observed. It is concluded that aerogenic vaccination offers no immunological advantage over vaccination by the subcutaneous route. |
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