两种氧气湿化液与呼吸道感染相关性研究

目的:进行冷开水和灭菌水两种氧气湿化液与呼吸道感染的相关性研究,从而加强对氧气湿化液的管理,规范氧气湿化液的使用。方法:将符合条件的吸氧病人随机分成两组,实验组采用冷开水,对照组采用灭菌水吸氧。分别收集吸氧前、24小时更换氧气湿化液时及停氧时的湿化液标本,同时收集吸氧前和停氧时的咽拭子培养和痰培养标本,氧气湿化液与临床标本检出同种病原体时,采用脉冲场凝胶电泳技术研究两者的相关性。结果:两组湿化液在使用前及使用后污染率差异无统计学意义,病人均未发生呼吸道感染,同一个病例湿化液标本与临床标本未检出同种病原体。结论:采用冷开水作为氧气湿化液避免了制作灭菌水的人力和物力资源的消耗,同时又可以节省病人的医疗费用。

Relevance of Two Kinds of Oxygen-humidified Water and Respiratory Tract Infections

Objective： To explore the correlation of the cold-boiled water and sterile water separately as oxygen-humidified water and respiratory tract infections, then strengthen the management of the oxygen-humidified water. Methods： We randomly divided the eligible inpatients into two groups. The experimental group used cold-boiled water while the control group used sterile water as oxygen-humidified water. Bacteria species and quantity of oxygen-humidified water were detected at baseline, 24 hrs, and the end of oxygen use. Meanwhile we detected the bacteria species and quantity of the swallow swab and sputum samples of the two groups before and after using oxygen. If same bacteria were found between humidified water and clinical samptes, we would use impulse gel electrophoresis method to identify their relationships. Results： The contamination rate of two kinds of water before and after using was not significantly different （P〉0.05）, and neither of the two groups had respiratory tract infections. The same pathogen had not been found. Conclusion： Using cold-boiled water as oxygen-humidified water could be cost effective for patients who need to use oxygen.