Risk-factors for emerging bloodstream infections caused by extended-spectrum β-lactamase-producing Escherichia coli |
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| Authors: | J. Rodrí guez-Bañ o,M. D. Navarro,L. Romero,M. A. Muniain,M. de Cueto,J. Gá lvez,E. J. Perea, A. Pascual |
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| Affiliation: | Sección de Enfermedades Infecciosas, Servicio de Medicina Interna;, Servicio de Microbiología, Hospital Universitario Virgen Macarena;, Departamento de Medicina;and Departamento de Microbiología, Universidad de Sevilla, Sevilla, Spain |
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| Abstract: | Risk-factors for bloodstream infections caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli were investigated using an exploratory case-double control study in which 43 cases (70% producing CTX-M enzymes) were compared with: (i) 86 patients with bacteraemia caused by non-ESBL-producing E. coli ; and (ii) 86 hospitalised patients. Previous follow-up as an outpatient, urinary catheterisation and use of oxyimino-β-lactams or fluoroquinolones were independent risk-factors for ESBL-producing E. coli among patients with E. coli bacteraemia, and previous use of oxyimino-β-lactams or fluoroquinolones were also independent risk-factors among hospitalised patients. These findings may help in identifying patients at greater risk for bloodstream infection caused by ESBL-producing E. coli in endemic areas. |
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| Keywords: | Bacteraemia Escherichia coli extended-spectrum β-lactamases hospitalised patients risk-factors |
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