Effect of insulin on human erythrocyte membrane fluidity in diabetes mellitus |
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Authors: | Bryszewska M. Leyko W. |
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Affiliation: | (1) Department of Biophysics, Institute of Biochemistry and Biophysics, University of Lodz, Poland |
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Abstract: | Summary The effect of insulin in vitro on the fluidity of the human erythrocyte membrane in Type I (insulin-dependent) diabetic patients and healthy control subjects was investigated using a fluorescence technique. It was found that the addition of 10-9 mol/l porcine insulin significantly increased fluorescent probe lateral mobility in the membrane lipid layer but did not appear to produce any conformational changes of membrane proteins. |
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Keywords: | Insulin erythrocyte membrane lateral mobility Type I diabetes |
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