Enhanced acquisition of discriminative approach following intra-amygdala d-amphetamine |
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Authors: | Paul K Hitchcott Catherine J Harmer G D Phillips |
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Institution: | (1) Behavioural Neuroscience Laboratory, Department of Psychology, University of York, Heslington, York YO1 5DD, UK, GB |
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Abstract: | This study examined the role of the mesoamygdaloid dopamine projection in stimulus-reward learning. Bilateral post-session
intra-amygdala microinjections of d-amphetamine were carried out in rats during training in a discriminative approach task known to be sensitive to experimental
manipulations of the amygdala. The experiment consisted of two phases: discriminative approach training, and a subsequent
assessment of instrumental conditioned reward efficacy. During discriminative approach training, subjects were trained to
associate a neutral stimulus with 10% w/v sucrose reward. Each trial consisted of a 1-s light stimulus followed by a 5-s presentation
of the sucrose reward. Approach behaviour into the recess housing sucrose reward was measured during each trial. Inappropriate
approach behaviour (approach outside of the trial periods) was punished by delaying the next trial. Intra-amygdala d-amphetamine (10 μg/side) enhanced the rate of acquisition of discriminative approach behaviour. This effect was most evident
early during training (sessions 2–4) and by the tenth session both groups had reached similar asymptotic performance. Horizontal
and vertical activity increased slightly across sessions, but there was no indication of a differential effect of d-amphetamine. Thus, intra-amygdala microinjections of d-amphetamine enhanced selectively the acquisition of the stimulus-reward association. During a subsequent test of instrumental
conditioned reward, presentation of the conditioned light stimulus was made contingent upon performance of a novel lever-pressing
response (probability 0.5). Responding on a second, control lever was without programmed consequences. Sucrose reward was
not available at any point, and subjects were tested drug-free. In both groups the conditioned stimulus was found to possess
significant conditioned rewarding efficacy. Extraneous behaviour was increased in the d-amphetamine group but the rewarding properties of the conditioned stimulus were unaltered. These findings demonstrate that
the mesoamygdaloid dopamine projection modulates the acquisition of a stimulus-reward association, but is apparently without
subsequent effect on the rewarding efficacy of a conditioned stimulus.
Received: 24 October 1996/Final version: 28 February 1997 |
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Keywords: | Stimulus-reward learning Conditioned reward d-Amphetamine Dopamine Amygdala |
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