支气管肺炎患儿治疗前后血清NO、NOS和血浆ET水平检测的临床意义

目的：探讨支气管肺炎患儿治疗前后血清NO、NOS和血浆ET含量的变化。方法：分别应用放免法和化学法对44例支气管肺炎患儿进行了治疗前后血清NO、NOS和血浆ET水平进行了检测，并与35例正常健康儿作比较。结果：治疗前血清NO、NOS和血浆ET水平均显著高于正常儿（P〈0．01），治疗后的7d则与正常儿比较无显著性差异（P〉0．05）。结论：血清NO、NOS和血浆ET水平与疾病的发生和发展有密切的关系，其水平的检测具有重要的临床价值。

Clinical Significance of Changes of Serum NO, NOS and Plasma ET Levels in Children with Bronchopneumonia

Objective To explore the clinical significance of changes of serum NO,NOS and plasma ET levels after treatment in children with bronchopneumonia.Methods The plasma concentrations of ET were determined with radioimmunoassay(RIA) and serum NO,NOS contents were determined with biochemical methods both before and after treatment in 44 children with bronchopneumonia as well as in 35 controls.Results Before treatment,serum concentrations of NO,NOS and plasma ET levels in the patients were significantly higher than those in controls(P<0.01).After 7 days treatment,the levels of NO,NOS,ET in the patients were not much different from those in the controls(P>0.05).Conclusion Detection of serum NO,NOS and plasma ET levels were useful for assessment of therapeutic efficacy.