Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells |
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| Authors: | Diez Berenice Ernst Glenda Teijo María Julieta Batlle Alcira Hajos Silvia Fukuda Haydée |
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| Institution: | Porphyirins and Porphyrias Research Center (CIPYP), National Research Council (CONICET), Hospital of Clinics, University of Buenos Aires, Buenos Aires, Argentina. |
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| Abstract: | The effects of combined administration of doxorubicin (DOX) and vincristine (VCR), with 5-aminolevulinic acid photodynamic treatment (ALA-PDT), were analyzed in sensitive murine leukemic cell lines (LBR-) and DOX and VCR chemoresistant LBR-D160 and LBR-V160 cell lines. Low doses of DOX and VCR increased anti-cancer effect of ALA-PDT in LBR-cells. Decrease in cell survival was higher when the combination VCR+ALA-PDT was used compared to DOX+ALA-PDT. Resistant cell lines LBR-D160 and LBR-V160 were sensitive to ALA-PDT; however, no changes occured when combining therapies. Thus, ALA-PDT can overcome drug resistance and is a good candidate for using treating multidrug resistant (MDR) cells. |
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