A case of diffuse large B-cell lymphoma of the lung demonstrating diffuse ground-glass shadows |
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Authors: | Ogata-Suetsugu Saiko Maeyama Takashige Takeshita Masafumi Hamada Naoki Takayama Koichi Inoue Hiromasa Nakanishi Yoichi |
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Affiliation: | Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. |
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Abstract: | We report a case of 77-year-old woman suffering from breathlessness on exertion and dry cough. Chest computed tomography (CT) showed diffuse ground-glass shadows. A video-assisted thoracoscopic lung biopsy resulted in the diagnosis of diffuse large B-cell lymphoma (DLBCL). Gene rearrangement analysis using polymerase chain reaction (PCR) technique was performed on the cells in bronchoalveolar lavage (BAL) fluid, and showed the clonality of the immunoglobulin heavy chain (IgH) gene, supporting the diagnosis. DLBCL should be considered in the differential diagnosis of diffuse ground-glass shadows in the chest CT, and gene rearrangement analysis may have an impact on the diagnosis of pulmonary DLBCL. |
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