Fluoxetine suppresses palatability-induced ingestion |
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Authors: | J D Leander |
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Institution: | (1) Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, 46285 Indianapolis, IN, USA |
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Abstract: | Non-deprived rats were allowed 1-h access to a range of saccarin solutions from 0.001 to 0.1 M Na saccharin. Compared to a group of rats drinking tap water, the rats drinking the saccharin solutions ingested a great deal more fluid, with as much as 24–30 ml consumed of the 0.01 M concentration, compared to 3–5 ml in controls. Fluoxetine (IP) decreased this palatability-induced excessive consumption in a dose-related manner. Effects of 10 mg/kg fluoxetine were apparent for 48 h after injection. This effect on palatability-induced ingestion may relate to previously reported effects of fluoxetine on food consumption. |
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Keywords: | Palatability Ingestive behavior Fluoxetine Saccharin |
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