含泮托拉唑、左氧氟沙星的三联方案治疗幽门螺杆菌102例

目的探讨含泮托拉唑、左氧氟沙星的三联方案治疗幽门螺杆菌的有效性和安全性。方法将102例幽门螺杆菌（Helicobacter hpylori,Hp）阳性的消化性溃疡及慢性胃炎患者随机分为克拉霉素治疗组和阿莫西林治疗组,抑酸剂选用泮托拉唑,两组联合的抗菌药均含左氧氟沙星,疗程6d。各组在治疗1周内和治疗后4～8周分别检测Hp感染情况。结果含泮托拉唑、左氧氟沙星的三联方案Hp根除率为82.35%,克拉霉素治疗组Hp根除率与阿莫西林治疗组比较无显著性差异（84.62%vs80.0%,P〉0.05）。结论含泮托拉唑、左氧氟沙星联合克拉霉素或阿莫西林是安全有效的幽门螺杆菌根除方案。

Pantoprazole and levofloxacin-based triple regimen therapy for 102 cases of helicobacter pylori infection

Objective To explore the efficacy and safety of pantoprazole and levofloxacin-based triple regimen therapy for Helicobacter pylori infection. Methods 102 cases patients with Hpylori infection accompanied with peptic ulcer or chronic gastritis were randomly divided into clarithromycin treatment group and amoxicillin treatment group combined with pantoprazole and levofloxacin. The course of treatment was six days. The eradication rate of Hpylori was evaluated 1 week before and 4-8 weeks after treatment. Results The eradication rate of Hpylori for levofloxaein-based tripel regimen therapy was 82. 35%. The eradication rate of Hpylori （ 84. 62% ） in clarithromycin treatment group was not significantly higher than that （ 80. 0% ） in amoxicillin treatment group （ P 〉 0.05 ）. Conclusion Pantoprazole and Levofloxacin-based triple regimen therapy is effective and safe for Hpylori infection.