血管性痴呆的临床诊断和治疗

近年来,血管性痴呆(VaD)的定义和临床诊断标准逐渐建立。已有2个很好的工具可用于VaD的诊断———NINDS-AIREN和ADDTC。尽管NINDS-AIREN和NINCDS-ADRDA标准可用来区分单纯性VaD和单纯性Alzheimer病,但VaD与Alzheimer病的鉴别以及混合性痴呆的诊断仍然具有一定的挑战性。一系列研究已证实乙酰胆碱酯酶抑制剂治疗VaD的作用,它不但能改善认知功能,而且还对脑功能恢复也有一定的益处。

Clinical Diagnosis and Treatment of Vascular Dementia

The definition and diagnosis criteria of vascular dementia(VaD)are being developed gradually in recent years. NINDS-AIREN and ADDTC have been used successfully in the diagnosis of VaD. Relatively pure VaD and Alzheimer's disease (AD) can be differentiated by using the NINDS-AIREN and NINDS-ADRDA criteria. There remains some challenges in diagnosis of mixed dementia and differentiating VaD from AD. A series of studies have suggested the effect of acetylcholinesterase inhibitors in the treatment of VaD. They can not only improve cognitive function, but also have certain benefits in recovering brain function.