复方四黄液联合封闭负压引流技术持续灌注冲洗对骨科感染缺损性创面修复及WBC、CRP、ESR的影响

目的:观察复方四黄液联合封闭负压引流技术持续灌注冲洗对骨科感染缺损性创面修复及WBC、CRP及ESR的影响。方法:选取2012年9月1日—2014年9月30日在广东省中山市中医院显微创伤科治疗的感染缺损性创面患者90例,随机分为A组、B组、C组,每组30例。A组给予复方四黄液联合VSD持续灌注冲洗治疗,B组给予复方四黄液外敷治疗,C组给予VSD持续负压引流治疗。比较三组的创面肉芽生长情况,同时抽取静脉血检测治疗前后外周血白细胞(WBC)计数,检测C反应蛋白(CRP)含量,测定红细胞沉降率(ESR)。结果:A组治疗后第5天、第10天创面肉芽生长情况评分优于B组、C组,差异有统计学意义(P0.05);A组治疗后第5天、第10天WBC、CRP、ESR水平均优于B组、C组(P0.05)。结论:复方四黄液联合封闭负压引流技术持续灌注冲洗能有效促进骨科感染缺损性创面肉芽组织生长及组织修复,并能有效抑制炎症反应,促进创面愈合。

The Influence of Compound of Four Yellow Liquid in Combination with Vacuum Sealing Drainage for Continuous Infusion and Washing on Orthopaedic Infections Defective Wound Healing and WBC,CRP, ESR

Objective:To observe the clinical curative effect of the influence of compound of four yellow liquid in combination with vacuum sealing drainage (VSD) for continuous infusion and washing on orthopaedic infections defective wound healing and WBC and CRP and ESR.Methods:Ninety patients with infections defective wound who were treated in the Micro-traumatic Department of our hospital between Sept.1 of 2012 and Sept.30 of 2014 were chosen as the research objects,and randomly divided into Group A,Group B and Group C,with 30 cases in each group.The ones in Group A were given compound of four yellow liquid in combination with VSD for continuous infusion and washing,while the ones in Group B were only given compound of four yellow liquid for external application,and the ones in Group C were given VSD therapy.Then the three groups' growth of granulation tissue were compared;At the same time,venous blood was taken to measure WBC,CRP contents and ESR before and after the treatment.Results:On the 5th day and the 10th day after the treatment,the growth of granulation tissue of Group A was better than that of Group B and that of Group C,and the difference between them had statistical significance (P ＜0.05);At the same time,WBC,CRP and ESR levels of Group A was better than that of Group B and that of Group C (P ＜0.05).Conclusion:Compound of four yellow liquid in combination with VSD for continuous infusion and washing can effectively improve orthopaedic infections defective wound growth of granulation tissue and its recovery,and significantly inhibit inflammation reactions,and promote wound healing.