大黄毒性及其合理应用研究进展

大黄为临床常用药物，可用于多种疾病的治疗，也常被用于降脂减肥、延缓衰老等，但随着大黄的广泛应用，其不良反应报道日渐增多。如何更好地发挥大黄的防病治病疗效，避免和减少其毒副作用，趋利避害，越来越受到人们的关注。本文主要从大黄的肝肾毒性、遗传毒性、致癌性、生殖与胚胎毒性及合理应用减毒等几个方面对近5年有关大黄毒性及其物质基础的研究进行了总结分析，从而较为客观地理解大黄毒性的含义，探讨大黄不良反应发生的原因，以期为大黄的进一步研究与临床安全应用提供参考。

Progress on Toxic Effect of Rhubarb and its Reasonable Use

Rhubarb is a common clinical drugs and can be used to the treatment of various diseases. In addition, rhubarb is often used to lipid-lowering diet, anti-aging and so on. But with the extensive application of rhubarb, its adverse reactions is increasingly recorded. More and more attentions are given to that how to better prevent and treat diseases, and avoid and minimise the toxic side effects of rhubarb. This paper analyze and summarize the study of rhubarb toxicity and its material basis during the nealy five years mainly from hepatorenal toxicity, genetic toxicity, carcinogenicity, reproductive and embryo toxicity, as well as reasonable application. Thus we can understand the meaning of rhubarb toxicity more objectively and explore the causes of rhubarb adverse reactions, in order to provide proper reference for its further research and clinical safe use.