红景天苷对神经退行性疾病作用的研究进展

红景天苷（Salidroside，Sal）是景天科植物红景天的主要活性成分之一。研究显示，Sal 在帕金森病（Parkin-son's disease，PD）、阿尔茨海默病（Alzheimer's disease, AD）和亨丁顿舞蹈症（Huntington's disease, HD）中的氧化和抗氧化系统起到双向调节作用。此外，Sal在PD和AD中可通过维持线粒体功能、减少ROS生成和增加抗凋亡蛋白和凋亡蛋白的比例以抑制细胞凋亡，进而促进神经元存活。但其在神经退行性疾病中的具体机制，如Sal通过哪种机制调控线粒体形态和功能的稳定以及Sal在疾病模型中的体内代谢分布改变等，仍有待进一步深入研究和临床验证。本文仅就Sal对神经退行性疾病的作用研究进展进行综述，为进一步研究提供参考。

Progress on the Role of Salidroside in Neurodegenerative Diseases

Salidroside (Sal) is one of the main active ingredients in Rhodiola belonging to Crassulaceae. Studies show that Sal plays a role in the regulation of both excitatory and inhibitory in the oxidation and antioxidant system in the Parkinson's disease (PD), Alzheimer's disease (AD) and Huntington's disease (HD). In addition, Sal can inhibit the apoptosis by maintaining the mitochondrial function, accelerating the reduction of ROS generation and increasing the proportion of anti apoptosis and apoptosis proteins, and then promote the survival of neurons in PD and AD. Therefore, it has broad potential application in the clinical treatment and prevention of neurodegenerative diseases. However, the specific mechanisms of Sal, such as what is the mechanism of stabling the mitochondrial morphology and function, and the changes of the metabolic distribution in the neurodegenerative disease model, which are still need to be further studied both in vitro and in vivo study. This paper reviews the role of salidroside in neurodegenerative diseases and provides reference for further study.