加味柴胡疏肝散治疗功能性消化不良（肝郁气滞证）临床疗效观察

目的：探讨加味柴胡疏肝散治疗功能性消化不良（肝郁气滞证）的临床疗效及其对胃电图的影响。方法选择符合纳入标准的功能性消化不良肝郁气滞证患者120例，随机分为观察组和对照组各60例，观察组服用加味柴胡疏肝散，对照组口服泮托拉唑肠溶胶囊及多潘立酮片剂，观察比较两组治疗后的临床疗效、中医证候积分变化及胃电频率与幅值的变化情况。结果观察组总有效率91.67%，对照组总有效率78.33%，两组比较差异有统计学意义（P＜0.05）；两组治疗后较治疗前中医证候积分均有所降低，且观察组优于对照组，差异有统计学意义（P＜0.05）；两组治疗后空腹及餐后的胃电频率及幅值均较治疗前明显提高，且观察组优于对照组，差异有统计学意义（P＜0.05）。结论加味柴胡疏肝散治疗功能性消化不良肝郁气滞证患者疗效确切，能明显改善中医证候，提高胃电频率和幅值，增加胃动力，安全无副作用，值得临床推广。

Clinical Curative Effect of the Modified Chaihu Shugan Powder on Functional Dyspepsia (Liver Depression and Qi stagnation Syndrome)

Objective To investigate the clinical curative effect of the modified Chaihu Shugan powder on functional dyspepsia (FD) (liver depression and Qi stagnation syndrome) and the influence on electrogastrogram (EGG). Methods 120 cases of patients that meet the standards of functional dyspepsia (liver depression and Qi stagnation syndrome) were selected and randomly divided into observation group and control group, 60 cases in each group. The observation group was treated with modified Chaihu Shugan powder, the control group on the basis of general treatment was given with pantoprazole enteric capsules and domperidone tablets orally. The clinical efficacy, the change of TCM syndrome integral and the variation of EGG of the two groups after treatment were observed. Results The total effectiveness of observation group was 91.67%, control group was 78.33%, the differences between two groups were statistically significant (P<0.05). The change of TCM syndrome integral of two groups were obviously improved, the control group was superior to observation group, the difference was statistically significant (P<0.05). After treatment, the fasting and postprandial gastric electrical frequency and amplitude in two groups were obviously improved, the control group was superior to observation group, the difference was statistically significant (P<0.05). Conclusion The modified Chaihu Shugan powder shows emarkable curative effect on treating functional dyspepsia liver depression and Qi stagnation syndrome patients. It can improve gastric electrical frequency and amplitude, boost the gastric dynamics, is worthy of clinical popularization and application.