中药复方防治脑梗死机制研究进展

脑梗死是临床常见性、多发性脑血管病，现代医学多以超早期溶栓、神经细胞保护、介入和外科手术等治疗为主，虽然近期疗效显著，但无法避免的副作用及严格的治疗准入条件使其临床应用大受限制。中医学整体审察、辨证论治的诊疗观以及复方多靶点、多环节、多途径、网络整合调节的治疗特点，在脑梗死防治方面有着不可或缺的优势。基于此，本文拟从抗氧自由基损伤、抑制凋亡基因激活、促进血管内皮生长及神经再生等方面系统综述中药复方治疗脑梗死的作用原理，以期为中医药防治缺血性脑血管疾病提供部分科学循证依据。

Research Progress of the Mechanism of Chinese Herbal Compound in Treatment of Cerebral Infarction

Cerebral infarction is a common clinical and multiple ischemic cerebrovascular disease, which treatment methods of modern medicine are mainly including early thrombolytic therapy, nerve cell protection therapy, interventional therapy, surgical therapy and so on. Eventhough recent therapeutic efficacy of theses methods is significant, their clinical application is limited due to the unavoided side effects and strict treatment access conditions. Chinese medicine has an indispensable advantage in treatment of cerebral infarction for the concept of wholism of diagnosis and syndrome differentiation. Chinese herbal formulation has multi-targets, multi-link, multi-way and network overall adjustment advantage. In this article, we will systematically review the principle of action of Chinese herbal formulation in treatment with cerebral infarction from anti-oxidative damage, inhibition of ecitability amino acid and overload of calcium, inhibition of apoptotic cell activation and promotion of vessel endothelial growth factor nerve regeneration. That is to provide the scientific evidence for prevention and treatment of ischemic cerebrovascular disease by Chinese medicine.