喷他佐辛超前镇痛在人工流产术中的应用

目的探讨喷他佐辛超前镇痛复合丙泊酚静脉全麻在人工流产术中的作用。方法175例ASAI级全麻下人工流产患者，随机均分为5组。P10组、P5组和P1组分别于麻醉前10分钟、5分钟和1分钟静脉注射喷他佐辛30mg，F组于术前10分钟静脉注射芬太尼1μg／k，C组为对照组。各组均静脉注射丙泊酚2mg／kg作全麻诱导，术中出现体动追加丙泊酚1mg／kg。观察各纽术中血压、心率及血氧饱和度。记录丙泊酚总用、麻醉诱导时间、唤醒时间和定向力恢复时间及丙泊酚注射、术中患者体动、呼吸抑制和术后恶呕发生情况。术后作VAS评分及患者满意度调查。结果研究组术中血压、心率、丙泊酚总用量、丙泊酚注射痛发生率、患者术中体动发生率、唤醒时间和定向力恢复时间较C组显著降低或缩短。F组术中呼吸抑制发生率显著高于其余4组。VAS评分，P5组和P1组显著高于C组，而P10组与F组相似（P〉0．05），但显著低于P5组和P1组（P〈0．05）。P10组术后患者满意度显著优于其余4组。结论喷他佐辛30mg超前镇痛用于人工流产术与芬术尼1μg/kg具有相似的镇痛效果，而无芬太尼的呼吸抑制作用，其较佳的给药时机为术前10分钟。

The appolication of Pentazocine pre emptive analgesia on artificial abortion

Objective To investigate the effect of Pentazocine preemptive analgesia combined with propofol intravenous anesthesia on artificial abortion. Methods 175 ASA I induced abortion patients were randomly allocated into 5 groups. P10 group, P5 group, and P1 group was administrated 30 mg Pentazocine at the time of 10 minutes, 5 minutes and 1 minute before the operation respectively, as well as F Group was administrated fentanyl 1 μg/kg at 10 minutes before the operation, and all the 4 groups above combined with intravenus anesthesia with 2 mg/kg propofol. C Group was administrated propofol 2 mg/kg as control group. HR, MAP and SpO2 were mornitored during the operation. Induction time, recovery time, propofol dosage and side effect were recorded. The anesthesia efficacy was assessed by the VAS and the overall satisfation of patients. Results HR, MAP, propofol consumption and the incidences of side effects during the operation in C group were significantly higher than the others. More possibility of respiratory depression was observed in F group than the others. The VAS of P5 group and PI group were superi- or than that of the C group, at the same time, the VAS of P10 group was inferior than that of the P5 group and Pl group, which makes no difference to that of the F group. The overall satisfaction in Pl0 group was higher than the others significantly. Con- clusion The method of 30 mg dose of Pentazocine pre - emptive analgesia combined with propofol intravenous anesthesia on arti- ficial abortion has a similar effect to those of 1 μg/kg dose of fentanyl. Moreover, it has no respiratory depression. The best time for the medicine application is 10 minutes before operation.