幽门螺杆菌感染与胃癌及胃部病变的多组病例对照研究

目的：探讨幽门螺杆菌（Helicobacter pylori，Hp）感染与胃癌及胃部病变之间是否存在因果关系。方法：将1994～1996年经病理确诊的胃癌及胃部病变病例分为多个病例组及对照组，利用1987年山东胃癌高发区组织库,作为Hp暴露史测量的资料。结果：调整年龄、性别及文化程度3个外部变量后，胃窦慢性浅表性胃炎、消化性溃疡及炎症活动程度与Hp感染间OR分别为2.072、2.980、2.086,有统计学关联，且差异有显著性。相关分析表明胃病严重程度与Hp感染之间存在负相关关系(r=－0.217)。结论：Hp感染与胃窦慢性浅表性胃炎、消化性溃疡及炎症活动程度存在部分因果关系。

Multi-groups controled study on the association of Helicobacter pylori infection with gastric cancer and stomach diseases

SUMMARY Objective: This multi group case control study was performed to determine whether Helicobacter pylori infection was associated with gastric cancer and stomach diseases. Methods: Gastric cancer and stomach disease patients that were diagnosed pathologically between 1994 and 1996 years were divided into several case groups and control group, all histological specimens collected in gastric cancer high risk region of Shandong Province were used to measure exposure history. Results: After variables concerning age, sex and education were adjusted, odds ratios of chronic superficial gastritis in antrum, peptic ulcer disease and active degree of inflammation associated with H. pylori infection remained significant (OR was 2.072, 2.980, 2.086 respectively). Correlation analyses showed negative relationship between degree of stomach diseases and H. pylori infection( r =-0.217). Conclusion: The results support the hypothesis of a relationship between H. pylori infection and the development of chronic superficial gastritis in antrum, peptic ulcer disease and active degree of inflammation.