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A phase 2 study of the PARP inhibitor veliparib plus temozolomide in patients with heavily pretreated metastatic colorectal cancer
Authors:Michael J. Pishvaian MD  PhD  Rebecca S. Slack MS  Wei Jiang MS  A. Ruth He MD  PhD  Jimmy J. Hwang MD  Amy Hankin NP  Karen Dorsch‐Vogel RN  Divyesh Kukadiya MS  Louis M. Weiner MD  John L. Marshall MD  Jonathan R. Brody PhD
Affiliation:1. Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC;2. The University of Texas MD Anderson Cancer Center, Houston, Texas;3. Carolinas Medical Center, Charlotte, North Carolina;4. Jefferson Pancreas, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania;5. Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania;6. Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania
Abstract:
Keywords:colorectal cancer  mismatch repair genes  O(6)‐methylguanine‐DNA methyltransferase (MGMT)  phosphatase and tensin homolog deleted on chromosome 10 (PTEN)  temozolomide  veliparib
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