Neutralization of equine arteritis virus; enhancing effect of guinea pig serum |
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| Authors: | B. Hyllseth U. Pettersson |
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| Affiliation: | (1) Institute of Virology, Royal Veterinary College, Stockholm;(2) National Veterinary Institute, Stockholm;(3) Present address: Department of Microbiology, at the Wallenberg Laboratory, University of Uppsala, Uppsala, Sweden |
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| Abstract: | Summary Neutralization of equine arteritis virus (EAV) by antisera is usually enhanced in the presence of unheated guinea pig serum. The enhancing effect of unheated guinea pig serum could be reduced by heating or eliminated by absorption on a heterologous antigen-antibody system. Immune horse and rabbit sera were fractionated and the fractions containing IgG or IgM tested against EAV. Only IgG had a neutralizing and sensitizing effect. EAV belongs thus to viruses which are in part neutralized, in part sensitized by antiviral IgG. |
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