冠心病患者血清肿瘤坏死因子、白细胞介素-6水平及其关系

目的 :观察冠心病 （CHD）患者血清肿瘤坏死因子 （TNF）、白细胞介素 - 6 （IL- 6 ）的变化与临床意义。方法 :采用放射免疫分析法 （RIA）测定 45例 CHD患者及 30例健康者 （对照组 ）血清 TNF,IL- 6水平。结果 :CHD患者血清TNF,IL- 6水平均显著高于对照组 （P<0 .0 1） ,尤以心肌梗死患者为明显 （P<0 .0 1） ;心肌梗死组血清 TNF,IL- 6水平较心肌缺血组显著升高 （P<0 .0 1） ;急性心肌梗死患者血清 TNF,IL- 6水平高于陈旧性心肌梗死患者 （P<0 .0 5 ） ;心肌缺血组心功能 ～ 级患者血清 TNF,IL- 6水平较心功能 ～ 级患者升高显著 （P<0 .0 1） ;血清TNF水平与 IL- 6之间呈明显正相关 （r=0 .73,P<0 .0 1）。结论 :血清 TNF,IL- 6水平与 CHD病情严重程度密切相关 ,TNF,IL- 6可能参与 CHD的发生与发展。

Study of serum TNF,IL-6levels in patients with coronary heart disease a nd their relationship

AIM:To study the changes of serum tumor necrosis factor(TNF) and in terleukin-6 (IL-6) in patients with coronary heart disease (CHD) and their cli ni cal significance. METHODS:The serum TNF and IL-6 in 45 patients with C HD and in 30 healthy controls were determined by using radioimmunoassay (RIA). RESULTS:The serum TNF and IL-6 levels in patients with CHD were marked l y higher than those in the controls (P<0.01),and especially those in patient s wi th myocardial infarction were more obvious (P<0.01). The serum TNF and IL-6 leve ls in myocardial infarction were much higher than those in myocardial ischemia ( P<0.01). In patients with myocardial infarction,the serum TNF and IL-6 leve ls in AMI patients were higher than those in OMI patients (P<0.05). In myocardial isc hemia patients,the serum TNF and IL-6 level at heart function stages Ⅲ～Ⅳ, wer e higher than those at heart function stages Ⅰ～Ⅱ (P<0.01). The serum TNF le vel was obvious positively correlated with IL-6 (r=0.73,P<0.01). CONC LUSION:The levels of serum TNf and IL-6 are closely related to the severity of CHD. T he study has implied that TNF and IL-6 may contribute to the formation and prog ression of CHD.