吸入呋塞米对急性发作期支气管哮喘患者肺通气功能的影响

目的 探讨吸入呋塞米对急性发作期支气管哮喘（哮喘）患者肺通气功能的影响。方法 将６例经、中度发作期哮喘患者随机分为Ａ、Ｂ、Ｃ三组，每组各２０例。Ａ组吸入生理盐水５ｍｌ，Ｂ组吸入呋塞米５０ｍｇ（５ｍｌ，１０ｍｇ／ｍｌ），Ｃ组吸入０．１％沙丁胺醇溶液５ｍｌ。观察三组患者吸药后１５ｍｉｎ肺通气功能的变化。结果 吸药后１５ｍｉｎＢ、Ｃ组用力肺活量（ＦＶＣ）、第１ｓ用力呼气容积（ＦＥＶ１）、最在呼气流量（Ｐ

Effect of inhaled furosemide on lung function in patients with acute exacerbation of asthma

Objective To investigate the effect of inhaled furosemide on lung function in patients with acute exacerbation of asthma.Methods 60 patients with acute mild or moderate exacerbation of asthma were randomly divided into A, B and C group, each group contained 20 cases. The patients in group A inhaled 5ml normal saline as placebo-control, group B inhaled furosemide 50mg (5 ml, 10 mg/ml), group C inhaled 0.l% salbutamol solution 5 ml. The percent of forced vital capacity (FVC), forced expiratory volume in one second (FEV 1), peak expiratory flow (PEF), maximal expiratory flow at 50% vital capacity (V 50 ) and maximal expiratory flow at 25% vital capacity (V 25 ) to their normal predicted value as FVC%, FEV 1%, PEF%,V 50 % and V 25 % were measured before therapy and at 15 minutes after therapy. Results No significant difference was observed in the baseline lung function in the three groups. In group B and group C, FVC%, FEV 1%, PEF%, V 50 % and V 25 % all significantly increased in 15 minutes after inhalation, while in group A no significant change occured.Conclusion Furosemide given by inhalation can reduce the bronchoconstriction and ameliorate the lung function in patients with acute exacerbation of asthma.