科研创新,加快医院科研成果转化

目的探讨本地区近年来新生儿监护室内新生儿梅毒的发病率及新生儿梅毒筛查的应用价值。方法对1999年1月至2004年6月期间收入我院新生儿监护室的所有新生儿行静脉血梅毒血清筛查,应用血清不加热反应素试验(USR法),发现异常者行梅毒确诊试验,应用梅毒螺旋体颗粒凝集试验(TPPA法),同时异常者父母行USR及TPPA检查。结果筛查3521例新生儿中,USR检测阳性52例,筛查阳性发生率约1.48%,检测TPPA阳性及根据新生儿梅毒诊断标准确诊先天性梅毒49例,两者符合率94.23%。结论先天性梅毒在本地区常见,新生儿梅毒筛查USR法简便易行,可作为新生儿梅毒筛查的有效方法,为先天性梅毒的早期诊断及治疗提供有力依据,对降低其发病率及减少其严重并发症有重要意义。

Screening with serum on the congenital syphilis from neonatal intensive care unit(NICU)

Objective To study the sick rate of congenital syphilis and the value of screening on the neonatal syphilis.Methods Screening with venous blood on neonatal syphilis in all neonatal from NICU in late 5 years.Syphilis were screened by unheated serum regain test(USR),then syphilis were confirmed diagnosised by treponema pallidum particleassay(TPPA).Parents of congenital syphilis were tested by USR and TPPA. Results 52 out of 3521 cases (1.48%) werescreened syphilis positive by USR,And 49 cases were confirmed diagnosised by TPPA.Coincidence rate of detection withUSR or TPPA was 94.2%. Conclusion Congenital syphilis was a common disease in this district.Screening by USR canbe a useful way to diagnose it.And it also plays an important rale on decreasing the incidence and severe complicationof congenital syphilis.