Surgery for epilepsy in children with dysembryoplastic neuroepithelial tumor: clinical spectrum,seizure outcome,neuroradiology, and pathology |
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Authors: | Burçak Bilginer Dilek Yalnızoglu Figen Soylemezoglu Guzide Turanlı Ayşenur Cila Meral Topçu Nejat Akalan |
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Institution: | (1) Department of Neurosurgery, Hacettepe University School of Medicine, 06100 Ankara, Turkey;(2) Department of Pediatric Neurology, Hacettepe University School of Medicine, Ankara, Turkey;(3) Department of Pathology, Hacettepe University School of Medicine, Ankara, Turkey;(4) Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey |
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Abstract: | Introduction Dysembryoplastic neuroepithelial tumors (DNTs) were first described by Daumas-Duport et al. in 1988 as a typically cortical
tumor affecting young patients with long-standing, drug-resistant epilepsy.
Methods We reviewed the medical records of 29 patients with DNT between 1994 and 2007 at Hacettepe University Children’s Hospital
retrospectively; age at the time of surgery, age at seizure onset, electroencephalography (EEG), MRI, medical treatment, surgical
procedure, seizure outcome, and pathological findings were documented.
Results Male to female ratio was 15/14. Age at the time of evaluation ranged 4–24 years. Twenty-seven patients (93.1%) had complex
partial seizures, one (3.44%) had simple partial seizures, and one patient had generalized seizures. Preop interictal EEG
showed epileptiform discharges in 24 patients, while in five patients interictal EEG before surgery showed no epileptiform
discharges. Pathologically, 24 of our patients were classified as complex type and five as simple type. MRI showed temporal
lesion in 20 (68.9%) patients and nine patients had extratemporal DNT. We choose the type of surgery according to lesion and
the epileptojenic zone. Finally, 27 patients had Engel Class IA and two patients had Engel Class IB outcome.
Conclusion Complete resection of the lesion with epileptojenic zone is important for seizure-free outcome. Timing of surgery, extent
of surgery, and stopping antiepileptic drugs are still important factors. |
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Keywords: | Dysembryoplastic neuroepithelial tumor Epilepsy surgery Temporal lobectomy Amygdalohippocampectomy Lesionectomy |
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