精浆抗精子抗体与精液主要参数相关性分析

目的:了解男性不育症患者精浆抗精子抗体(AsAb)对精子主要参数的影响。方法:对126例男性不育症患者的精液标本进行精子质量分析,同时用金标免疫斑点法进行精浆抗精子检测,然后对检测抗精子抗体阳性和抗精子抗体阴性患者分组进行精子质量参数的统计学分析。结果:126例男性不育患者中,精浆抗精子抗体阳性44例,阳性率为34.9%;阴性82例,阴性率为65.1%。抗精子抗体阴性组精子密度、活动率、活动力等主要参数明显高于阳性组,两组比较,差异具统计学意义(P<0.01)。结论:抗精子抗体对精子有凝集和制动作用,对精子密度、活动率等主要参数有明显的影响,是导致男性免疫性不育的重要因素之一。

Correlation analysis of antisperm antibodies and main parameters of semen analysis

Objective To understand the influence of male infertility antisperm antibody （AsAb） on the main parameters of sperm in infertility.Method Total 126 cases of male infertility,sperm quality of semen samples were analyzed and immunofluorescence assay with gold for antisperm detection,then sperm quality parameters in anti-sperm antibodies positive and negative patients were statistical analyzed.Results Among 126 cases of male infertility patients,seminal plasma anti-sperm antibodies positive in 44 cases,the positive rate was 34.9%;negative in 82 cases,the negative rate was 65.1%.Sperm density,motility,activity and other major parameters in anti-sperm antibody-negative group was significantly higher than that of the positive group,showed statistically significant difference （P0.01）.Conclusion Anti-sperm antibody has aggregation and braking effect on sperm density,motility and other main parameters,are the main factor led to male immune infertility.