| ABCG2基因单核苷酸多态性研究进展 |
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| 引用本文： | 肖宇山,胡丽莉. ABCG2基因单核苷酸多态性研究进展[J]. 广东药学院学报, 2010, 26(5): 540-545. DOI: 10.3969/j.issn.1006-8783.2010.05.027 |
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| 作者姓名： | 肖宇山 胡丽莉 |
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| 作者单位： | 广东药学院,生命科学与生物制药学院,广东,广州,510006;广东药学院,生命科学与生物制药学院,广东,广州,510006 |
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| 基金项目： | 广东药学院科研启动基金项目 |
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| 摘 要： | ABCG2是一种ATP结合转运蛋白,在人的正常细胞和肿瘤组织中均有表达,具有抑制消化道吸收某些外源性物质,参与形成血脑、胎血屏障等生理功能。同时ABCG2也是新的药物排出泵,是肿瘤多药耐药的重要机制之一。ABCG2基因的单核苷酸多态性（single nucleotide polymorphism,SNP）可能影响ABCG2蛋白的表达与功能,与疾病的易感性及药动学等相关。ABCG2单核苷酸多态性的研究成为新的研究热点,本文就近年来国内外关于ABCG2基因SNP的研究进行综述。
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| 关 键 词： | ABCG2基因 单核苷酸多态性 |
Research progress of single nucleotide polymorphism in ABCG2 gene |
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| XIAO Yu-shan,HU Li-Li. Research progress of single nucleotide polymorphism in ABCG2 gene[J]. Academic Journal of Guangdong College of Pharmacy, 2010, 26(5): 540-545. DOI: 10.3969/j.issn.1006-8783.2010.05.027 |
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| Authors: | XIAO Yu-shan HU Li-Li |
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| Affiliation: | XIAO Yu-shan,HU Li-Li(School of Life Science and Bio-pharmacology,Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China) |
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| Abstract: | ABCG2 protein is one of the ATP-binding transporters expressed in human normal cells and tumor tissues,ABCG2 can inhibit the gastrointestinal absorption of which can be exogenous substances,involved in many physiological functions such as the formation of the blood-brain and placental-blood barrier.ABCG2 is a new drug efflux pump as well.It is one cause of multidrug resistance.ABCG2 gene single nucleotide polymorphism may affect the expression and function of ABCG2 protein.ABCG2 gene SNP is associated with ... |
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| Keywords: | ABCG2 gene single nucleotide polymorphism |
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