番茄红素对高脂血症大鼠血脂及红细胞的影响

目的 研究番茄红素对高脂血症大鼠血脂及红细胞的影响.方法 成年雄性SD大鼠48只,根据总胆固醇(TC)水平、体重随机分为6组:正常对照组(A组),基础饲料喂养;高脂模型组(B组),高脂饲料喂养;阳性药物对照组(C组),高脂饲料+氟伐他汀钠10 mg·kg~(-1)·d~(-1);番茄红素D组(高脂饲料+番茄红素11 mg·kg~(-1)·d~(-1))、E组(高脂饲料+番茄红素22 mg·kg~(-1)·d~(-1))、F组(高脂饲料+番茄红素44 mg·kg~(-1)·d~(-1)),灌胃处理.各组大鼠均于实验开始第0、1、3周末取尾静脉血检测血清TC、甘油三酯(TG)等的含量.第3周末检测血红蛋白(HGB)、红细胞计数(RBC)等相关参数.结果 高脂饲料喂养1周后,大鼠形成高脂血症;实验结束,A、B、C、D、E、F组TC分别为(1.31 4-0.05)、(19.40 ±0.54)、(4.66 ±0.07)、(7.18 ±0.06)、(5.30 ±0.28)、(4.49±0.23)mmol/L(F=4395.72,P=0.00);TG分别为(0.42 ±0.01)、(2.29±0.42)、(0.69 ±0.03)、(1.10 ±0.05)、(0.63 ±0.02)、(0.62 ±0.04)mmol/L(F=127.26,P=0.00);HGB分别为(143.13 ±6.33)、(112.63 ±2.56)、(124.75 ±3.62)、(124.63 ±7.78)、(132.38 ±6.41)、(142.13 ±5.54)g/L(F=34.14,P=0.00);RBC分别为(6.75 ±0.60)× 10~(12)/L、(5.08 ±0.75)×10~(12)/L、(7.14±0.82)×10~(12)/L、(5.94 ±1.09)× 10~(12)/L、(6.18 ±0.36)× 10~(12)/L、(7.31 ±0.58)× 10~(12)/L(F=10.35.P=0.00).结论 番茄红素可能通过调节血脂和抗氧化而发挥其对红细胞的保护作用.

Effects of lycopene on blood lipid and red blood cell of rat with hypercholesterolemia

Objective To study the effect of lycopene on red blood cell and the level of blood lipid. Methods According to the level of serum total cholesterol and weight,forty-eight adult male SD rats were divided randomly into six groups; normal control (group A) ,fed by normal feed; hyperlipidemia group cholesterol(TC) and total triglyceride(TG) were measured at the end of 0,1,3 weeks of the study by taking samples from tail vein. At the end of the experiment, RBC and HCB were measured. Results After the rats were fed with high-fat feed for a week, models of hyperlipidemia rats were established. At the end of 3 weeks,TC of group A,B,C,D,E and F were (1.31 ±0. 05), (19.40 ±0. 54) , (4. 66 ±0. 07), (7. 18 ±0. 06), (5. 30 ±0.28), (4.49 ± 0. 23) mmol/L( F = 4395. 72, P = 0.00), respectively; and TG were (0.42 ±0.01),(2. 29 ±0.42), (0.69 ±0.03),(1. 10 ±0.05),(0.63 ±0. 02), (0. 62 ±0.04) mmol/L(F =127. 26,P = 0. 00), respectively; HGB were (143. 13 ± 6. 33 h (112. 63 ± 2. 56), (124. 75 ± 3. 62 ),(124. 63 ±7. 78) , (132. 38 ±6. 41), (142. 13 ±5. 54)g/L( F = 34. 14,P =0. 00),respectively;RBC were (6. 75 ±0.60) ×10~(12)/L,(5.08±0.75) × 10~(12)/L, (7. 14 ± 0. 82) × 10~(12)/L, (5. 94 ± 1. 09) × 10~(12)/L, (6. 18 ±0.36) × 10~(12)/L and (7.31 ±0.58) × 10~(12)/L ( F= 10. 35, P= 0. 00), respectively. Conclusion Lycopene have some protective effects on red blood cells of the hyperlipidemic rats by regulating the blood lipid and antioxidant.