The effect of Trolox-vitamin E analog on placental lipid peroxidation with physiologic pregnancies and pregnancies complicated by pre-eclampsia

There are suggestions that free radicals are involved in some dysfunctions observed in preeclampsia. In this study we have examined the effect of Trolox (water soluble vitamin E analog) on placental lipid peroxidation. Placentas from 20 normal and 20 preeclamptic woman were used in this study. Lipoperoxidative process was measured by means of Okhawa method. The level of lipid peroxides in preeclamptic placentas is higher than in normal placentas. In normal placentas 20 microM, of Trolox caused the greatest fall in MDA level (about 25%) in comparison with the control MDA level (only with peroxidative system without Trolox). In preeclamptic placentas the greatest fall in lipooxygenation process (about 14%) was caused by 25 microM. of Trolox. The influence of Trolox on the level of lipid peroxides in preeclamptic placentas is less effective in comparison with normal placentas.