布洛芬-壳聚糖缓释微囊药代动力学研究

目的研究自制布洛芬壳-聚糖微囊的药代动力学。方法以市售布洛芬普通片剂为参比通过高效液相色谱测定模型动物家兔药时曲线。结果相对于普通片剂,兔口服布洛芬-壳聚糖微囊后,达峰时间明显推迟,且达峰浓度降低（P〈0.05）;同时药物在兔体内平均驻留时间明显长于普通片（P〈0.05）;但两制剂的AUC无差异（P〉0.05）。结论研制的布洛芬-壳聚糖微囊具有较好的缓释效果,且吸收程度与普通布洛芬片剂等效。

Study on Pharmacokinetics of ibuprofen-Chitosan Microcapsules

OBJECTIVE To study the pharmacokinetics of ibuprofen-chitosan microcapsules.METHODS Taking conventional ibuprofen tablets as control,and high preformance liquid chromatography（HPLC）was used to determine drug concentrationtime curve in rabbits.RESULTS Compared with the conventional tablets,the sustained-release ibuprofen-chitosan microcapsules have longer action time in rabbits,and the peak time was obviously delayed,the peak concentration was decreased.but the AUC of them was not different statistically（P0.05）.CONCLUSION The prepared ibuprofen-chitosan microcapsules has a better sustained drug release effect,and the absorption degree of them was equivalet.