Malignant fibrous histiocytoma: an institutional review |
| |
| Authors: | Gibbs J F Huang P P Lee R J McGrath B Brooks J McKinley B Driscoll D Kraybill W G |
| |
| Affiliation: | a Division of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, New York, U.S.A.b Division of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.c Department of Pathology, Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, New York, U.S.A. |
| |
| Abstract: | Background: A thorough understanding of malignant fibrous histiocytoma (MFH), the most common subtype of soft tissue sarcoma, will lead to improved histologic-specific protocols. Methods: 126 patients with histologically confirmed MFH were analyzed. The median follow-up was 42 months (range 1-233 months). Results: Overall survival was 58% at 5 years and 38% at 10 years. Grade significantly influenced prognosis, with 10-year survival of 90%, 60%, and 20% for low, intermediate, and high grade tumors, respectively (p = 0.0007). Distant metastases at initial presentation (p = 0.0002) and size of the primary tumor (p = 0.0007) influenced outcome. Neither anatomic site nor depth of the primary tumor were significant prognostic factors. Positive microscopic margins were associated with a decreased disease-free survival (p = 0.006). Conclusions: Tumor grade, size, and distant metastases at initial presentation remain the most important prognostic factors for MFH. Resection with negative microscopic margins decreased the incidence of local recurrence. |
| |
| Keywords: | |
| 本文献已被 InformaWorld PubMed 等数据库收录！ |
|
