|
|||||
|
|
| 何首乌中二苯乙烯苷的药效学和药动学研究进展 | |
| 引用本文： | 王健鲲,朱萱萱,孙建国. 何首乌中二苯乙烯苷的药效学和药动学研究进展[J]. 中国临床药理学与治疗学, 2011, 16(12): 1426-1430 |
| 作者姓名： | 王健鲲 朱萱萱 孙建国 |
| 作者单位： | 1. 南京中医药大学药学院,南京210046,江苏;中国药科大学药物代谢动力学重点实验室,南京210009,江苏 2. 南京中医药大学药学院,南京210046,江苏;江苏省中医院,南京210029,江苏 3. 中国药科大学药物代谢动力学重点实验室,南京210009,江苏 |
| 基金项目： | “重大新药创制”科技重大专项(2009ZX09304-001,2009ZX09502-004) |
| 摘 要： | 二苯乙烯苷类成分是何首乌中的特有成分,具有广泛的药理学活性.本文综述了二苯乙烯苷(2,3,5,4’-四羟基二苯乙烯-2-O-β-D-葡萄糖苷)在抗氧化、心血管系统、中枢神经系统和抗肿瘤等药效学方面的作用,探讨了其可能的作用机制及应用前景.同时对其吸收和代谢等药动学方面的最新研究进展进行了总结,以期为进一步深入研究二苯乙烯苷类成分的药学特点和药物研发方向提供思路. |
| 关 键 词： | 二苯乙烯苷 药效学 药动学 |
Progress of pharmacological effects and pharmacokinetics of stilbene glycoside from Polygonum multiflorum Thunb |
|
| WANG Jian-kun , ZHU Xuan-xuan , SUN Jian-guo. Progress of pharmacological effects and pharmacokinetics of stilbene glycoside from Polygonum multiflorum Thunb[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(12): 1426-1430 | |
| Authors: | WANG Jian-kun ZHU Xuan-xuan SUN Jian-guo |
| Affiliation: | WANG Jian-kun1,2,ZHU Xuan-xuan1,3,SUN Jian-guo21 College of Pharmacy,Nanjing University of Traditional Chinese Medicine,Nanjing 210046,Jiangsu,China,2 Key Laboratory of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,3 Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210029,Chin |
| Abstract: | Stilbene glycosides, the special constituents in Polygonum multiflorum Thunb, were reported to be the active ingredients with various pharmacological effects. It is reviewed the research progress of the pharmacological effects of Stilbene glycoside （2, 3, 5, 4-tetrahydroxystilbene-2-O-β-D-glucoside） on antioxidant system, cardiovascular system, central nervous system and antitumor effects. The possible mechanism involved and its possible application are also discussed. Meanwhile, the advances in pharmacokinetics of stilbene glycoside such as absorption and metabolism are also summarized. Thus we can provide some new ideas and strategies for further indepth research on stilbene glycosides. |
| Keywords: | Stilbene glycoside Pharmacological effects Pharmacokinetics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |