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Breast conservative therapy for early breast cancer:a retrospective cohort study.

??Objective:o compare the effects of breast conservative therapy (BCT) with modified radical mastectomy (MRM) in women with early stage breast cancer. Methods: matched retrospective cohort study using data on patients derived from a prospectively collected breast cancer database was conducted.The database included patients who received MRM or BCT from 1995 to 2002 in Cancer Hospital of Fudan University.The match was conducted according with four variables:age at diagnosis,axillary lymph node status,sexual hormone receptor status and the dimension of tumor.The match ratio was 1??2.Controls were patients who received MRM (n=254).Cases were patients who received BCT (n=127).Median follow??up for the controls and cases were 58 months and 49 months respectively.The differences of incidence of loco??regional recurrence,disease free survival and overall survival at 5 years were compared.There were no significant differences in incidence of loco??regional recurrence,DFS and OS at 5 years between the two groups of patients. Results:he incidence of loco??regional recurrence was 1.4% in MRM group and 3??39% in BCT group (P=0.5).The OS in MRM and BCT patient were 97.7% and 96.73% (P=0.66).The DFS in MRM and BCT patients were 91.57% and 86??04% (P=0.37). Conclusion:For appropriate breast cancer patients,classic lumpectomy plus axillary lymph node dissection and post??operative radiotherapy lead to excellent local control and good survival rate.The BCT can result in the same effects as MRM in breast cancer patients with better cosmetic appearances.